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Reduced John's MDD, Subtypes of MDD can be viewed as ELS absent, Monoamine Neurotransmitters namely serotonin (5-hydroxytryptamine 5-HT), ACTH responses to CRF stimulation may reflect sensitization, Corticotrophin -Releasing Factor (CRF) stimulates production of Adrenocorticotropin (ACTH), Brain-derived neurotrophic factor PROTEIN (BDNF) stabilizes synaptic contacts, sprouting in dendrites, support systems can increase AMPA receptor, Exposure reduces Neurogenesis, Depression-like states in Animal Models, Monoamine Neurotransmitters affect ADAPTIVE changes in NEURONS