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BD Final JDN Rev, Age of onset is variable, prevalence is about 1-1.5%, Genetic methodologies include familial studies, Linkage has been a blunt instrument, BD I characterized by Depressive Episode, Cyclothymia characterized by chronic fluctuations, debate only diagnosed following 1 or more manic episode, recurrent averages 4 epsiodes in 10 years, 1 or more manic episode at least 1 week of (or hospitalization for) Elevated/euphoric mood, Concordance Rates determined from Family Studies